Calcium EDTA complex | C10H14CaN2O8 - PubChem Komplex Thrombophlebitis
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This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. To view content sources and attributions, please refer to our editorial policy. We comply with the HONcode standard for trustworthy health information - verify here, Komplex Thrombophlebitis. Skip to Content googletag, Komplex Thrombophlebitis. DX Commonly used brand name s: Other commonly used names are calcium EDTA, edathamil calcium disodium, and sodium calcium edetate.
For a listing of dosage forms and brand names by country availability, see Dosage Forms section s. Chelating agent— diagnostic aid, lead mobilization— Indications Note: Bracketed information in the Indications section refers to uses that are not Komplex Thrombophlebitis in U.
Accepted Toxicity, lead treatment —Edetate calcium disodium is indicated for the treatment of acute and chronic lead poisoning plumbism and lead encephalopathy. Recovery is slow and often incomplete, with residual neurologic deficit. However, use of the lead mobilization test is controversial because of variable results, difficulty in collecting urine from non—toilet-trained children, possible increase in brain lead levels, and risk of Komplex Thrombophlebitis deficiency causing a negative mobilization result.
Edetate calcium disodium reduces blood concentrations and depot stores of lead. The oral route of administration is no longer used because of poor GI absorption. The absorption of any lead in the intestines may be increased upon oral administration of edetate calcium disodium because the lead chelate formed is more soluble than the lead itself.
After absorption, the chelate dissociates and releases free lead ions, producing increased symptoms of lead toxicity. No metabolism occurs; after parenteral administration, edetate calcium disodium is excreted in the urine either unchanged or as the metal chelates. Risk-benefit must be considered during early pregnancy or in women of child-bearing potential.
Another reproduction study performed in rats at doses up to 25 to 40 times the human dose revealed evidence of fetal malformations, which were prevented by simultaneous administration of zinc supplements.
Pediatrics Because the intramuscular route is painful and there may be poor blood flow to muscle, the die Thrombophlebitis diagnostizieren route is recommended for children. Except under special circumstances, this medication should not be used when the following Medizin als Krampfadern an den Beinen zu behandeln problems exist: Microscopic hematuria, proteinuria, or Komplex Thrombophlebitis renal epithelial cells may be observed in urine.
Concentration of solution should not exceed 0, Komplex Thrombophlebitis. The dosage schedule should be followed and the recommended daily dose must not be exceeded Komplex Thrombophlebitis of the toxic and potentially fatal effects of edetate calcium disodium, Komplex Thrombophlebitis. However, the intravenous route is preferred because the intramuscular route is painful and children have poor blood flow to muscle. A final procaine or lidocaine concentration of 5 mg per mL 0.
When urine flow has been established, further intravenous fluids should be restricted Komplex Thrombophlebitis basal water and electrolyte requirements. The preferred route of administration for edetate calcium disodium is intravenous and dimercaprol is given by deep intramuscular injection in divided doses every 4 hours for 5 days.
If both drugs are given by intramuscular injection, then they must be given at separate sites. Dimercaprol is given alone for the first dose 4 hours before the combination is begun. Although use to date has been limited, toxicity appears Komplex Thrombophlebitis be less than with other agents.
At 20 mcg per deciliter, Komplex Thrombophlebitis evaluation should occur. Patients with blood lead levels between 45 and 69 mcg per deciliter Komplex Thrombophlebitis be treated with edetate calcium disodium alone using the same dosage given above for use with dimercaprol. If the serum creatinine is 2 to 3 mg per deciliter, the dosage is mg a day. Intravenous or intramuscular, in conjunction with dimercaprol, Komplex Thrombophlebitis, mg of edetate Komplex Thrombophlebitis disodium per square meter of body surface area a day, administered on a four-hour schedule for 5 days.
Some clinicians prefer that edetate calcium disodium be given by continuous intravenous infusion. If given by intramuscular route, it must be given at a detraleks Tabletten bei Varizen site from dimercaprol.
Children with blood lead levels between 45 and 69 mcg per deciliter may be treated with edetate calcium disodium alone, using a dose of mg of edetate calcium disodium per square meter of body surface area a day for 5 days.
Therapy should continue if blood lead levels are greater than 45 mcg per dL. Preparation of dosage form: Intravenous—Dilute 1 gram of edetate calcium disodium with to mL of 0, Komplex Thrombophlebitis. Lilis R, et al. Chelation therapy in workers exposed to lead. JAMA ; CDC Preventing lead poisoning in young children, AHFS Drug information American Society of Hospital Pharmacists, Diagnosis and treatment of human poisoning. Drug facts and comparisons. Facts and Comparisons, Inc.
AMA Drug evaluations, Komplex Thrombophlebitis, Annual Goodman and Gilman's the pharmacological basis of therapeutics, 8the ed. Chisolm J, Bartrop D, Komplex Thrombophlebitis. Recognition and management of children with increased lead absorption, Komplex Thrombophlebitis. Arch Dis Child ; Saenger P, et al. Diagnostic significance of edetate disodium calcium testing in children with increased lead absorption.
Am J Dis Child ; Conn's current therapy Cecil textbook of medicine. The use of chelating agents in the treatment of acute and chronic lead intoxication in childhood. J Pediatr ; Markowitz M, Rosen J, Komplex Thrombophlebitis. Need for the lead mobilization test in children with lead poisoning. Komplex Thrombophlebitis toxicology of commercial products. The Williams and Wilkins Co.: Perry H, Schroeder H, Komplex Thrombophlebitis. Lesions resembling vitamin B complex deficiency and urinary loss of zinc produced by ethylenediaminetetraacetic acid.
Am J Med ; Assessment of lead stores in children: Dose-response study of oral 2,3-dimercaptosuccinic acid in children with elevated blood lead concentrations.
Mobilization of lead by calcium disodium edetate. Effects of iron deficiency on lead excretion in children with moderate lead intoxication. Thomas D, Chisolm J. Lead, zinc and copper decorporation during calcium disodium ethylenedeamine tetraacetate treatment of lead-poisoned children. J Pharm Exp Ther ; : Reviewers' consensus on monograph revision of Juluca Juluca dolutegravir and rilpivirine venotoniki wirksam Krampf a single-tablet, two-drug regimen of the approved drugs Hemlibra Hemlibra emicizumab-kxwh is a bispecific factor IXa- and factor X-directed antibody indicated to Mepsevii Komplex Thrombophlebitis Fasenra benralizumab is an interleukin-5 receptor alpha-directed cytolytic monoclonal antibody
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Nov 10, Author: Therefore, Komplex Thrombophlebitis, treatment remains primarily supportive in most cases. This is consonant with the understanding that HSP is a self-limited disease. The majority of patients recover quickly ie, within several weeks without treatment. Management of HSP includes adequate ob es möglich ist, Thrombophlebitis zu verhungern immediate discontinuance of any exposure to antigenic stimulants eg, drugs ; and follow-up each week for the first month, every other week for the second month, and monthly thereafter until abnormal urinary findings subside.
Patients with HSP are often admitted to the hospital and monitored for abdominal and renal complications, which may be severe and may occur precipitously eg, acute abdomen, acute scrotum, and renal failure. Hospitalization should be strongly considered for HSP patients with severe abdominal pain, significant gastrointestinal GI bleeding, or marked renal insufficiency. HSP may mimic an abdominal emergency and, in its severest form, result in small-bowel infarction, perforation, or both.
In adults with HSP, permanent renal involvement is not uncommon. Hematuria at disease onset and persistence of renal manifestations during the occurrence of HSP can be significant predictors of possible development of renal sequelae. These manifestations, along with other features eg, onset in summer, anemia at disease onset, or relapses of the diseasemay predict the development of renal sequelae in most patients.
All pregnant women with even mild renal symptoms at the onset of HSP should be carefully observed during and after pregnancy.
Nephropathy is treated supportively. Various drugs eg, corticosteroids, Komplex Thrombophlebitis, azathioprine, and cyclophosphamide and plasmapheresis have been used to prevent renal disease from progressing. The results have been inconsistent. No data from controlled studies are available, Komplex Thrombophlebitis.
Dietary restrictions have no clear role Komplex Thrombophlebitis the management of HSP. Activities can be performed as tolerated. Treatment of HSP is primarily supportive and includes ensuring adequate hydration and monitoring for abdominal and renal complications. For minor complaints of arthritis, edema, fever or malaise, symptomatic treatment is advised, including use of acetaminophen, elevation of swollen extremities, eating a bland diet, and adequate hydration.
All unnecessary drugs should be discontinued if a drug-related etiology is suspected. Most patients with self-limited cases can be safely discharged home with close follow-up by the primary physician. Admission to the hospital is recommended for control of abdominal pain or vomiting, monitoring of renal function, confirming a doubted diagnosis, and observation and monitoring, Komplex Thrombophlebitis. Patients with renal involvement require Komplex Thrombophlebitis attention to their fluid balance, electrolyte status, and use of antihypertensives if indicated.
A study Komplex Thrombophlebitis prevention and treatment Komplex Thrombophlebitis renal disease in patients with HSP revealed no significant difference in the risk of persistent kidney disease at 6 months and 12 months in children given prednisone for days upon presentation in comparison with placebo or supportive treatment.
Pain control is essential for quality patient care, Komplex Thrombophlebitis. Analgesia with nonsteroidal anti-inflammatory drugs NSAIDs or acetaminophen may reduce joint and soft tissue discomfort.
Such agents are often effective and do not seem to worsen the purpura; however, they should be used cautiously in patients with Komplex Thrombophlebitis insufficiency, Komplex Thrombophlebitis.
Clinicians often use corticosteroids to treat subcutaneous edema and nephritis in HSP, as well as to ameliorate associated arthralgias and symptoms associated with GI dysfunction. However, good, large, prospective studies regarding the treatment of HSP are lacking, Komplex Thrombophlebitis, [ 585960 ] and the evidence does not yet support the use of steroids to prevent or treat renal disease.
Nevertheless, corticosteroids may be considered in the following situations:. A review of randomized clinical trials for any intervention used to improve renal disease in children with HSP noted that data were very limited except for short-term prednisone; moreover, prednisone had no benefit in preventing serious long-term renal disease.
The long-term Komplex Thrombophlebitis of HSP directly depends on the severity of renal involvement. Patients with HSP-related renal dysfunction may benefit from therapy. However, prophylaxis of renal complications in HSP, though interesting, is not currently recommended. Treatment of overt HSP includes methylprednisolone pulse therapy and prednisone and other immunosuppressive medications.
Antihypertensives may be indicated with renal involvement. Faedda reported favorable results from the following protocols in patients with severe HSP [ 65 ]:, Komplex Thrombophlebitis.
Of these, only cyclophosphamide has been shown to be effective in a randomized controlled trial, Komplex Thrombophlebitis. Although some studies have reported success, Komplex Thrombophlebitis, cyclosporine does not have sufficient clinical data to establish its utility in this setting. Azathioprine, mycophenolate mofetil, and urokinase must be tested before their use is consistently advocated.
Guidelines Komplex Thrombophlebitis prescribing azathioprine Komplex Thrombophlebitis dermatology have been established. A randomized clinical trial of cyclosporine with methylprednisolone pulses in HSP with nephritis found that cyclosporine was Komplex Thrombophlebitis and had many fewer complications.
In contrast, immunosuppressive therapy may lead to a persistent or worsening disease course in these patients. Dapsone has been used to treat associated purpuras and arthralgias.
Iqbal and Evans found it to be effective for HSP. Rituximab has been noted to be a successful treatment for severe refractory chronic HSP.
Factor VIII concentrate has been used to relieve abdominal pain when corticosteroids are contraindicated. Treatment of complicated HSP with mycophenolate mofetil has been reported in a series of patients. Komplex Thrombophlebitis may be effective in delaying the progression of kidney disease. A case series demonstrated good outcomes in adults with severe Komplex Thrombophlebitis who were treated with plasma exchange in addition to steroids.
Surgery may be undertaken to treat severe bowel ischemia. Kidney transplantation may be indicated in patients with severe renal disease that is resistant to medical therapy. Successful treatment of progressive HSP nephritis with tonsillectomy and corticosteroid pulse therapy has been reported, Komplex Thrombophlebitis.
Because HSP is a multisystem disease, consultations with the following specialists can be helpful in diagnosis and treatment:. Consultation is recommended for patients with renal involvement before discharge from the emergency department and for all patients who appear acutely ill. Blauer Ton aus Varizen all patients, urinalysis and blood pressure monitoring to evaluate for renal involvement should be Komplex Thrombophlebitis for up to 6 months after presentation, even if initial urinalysis results were Komplex Thrombophlebitis. Once the initial course of prednisone is administered, Komplex Thrombophlebitis, additional prednisone appears to have no role, Komplex Thrombophlebitis.
When terminal renal failure develops, long-term hemodialysis should be instituted until a kidney is available for transplantation. Mesangial deposits of IgA are common in the graft, but they rarely lead to clinical manifestations of recurrent glomerulonephritis. Children who have demonstrated renal manifestations in the acute phase and continue to have hematuria or proteinuria should be examined every months Komplex Thrombophlebitis renal failure or hypertension can develop up to 10 years after disease onset.
NSAIDs may be administered to address joint problems. Henoch-Schönlein purpura in adulthood and Varizen kalte Dusche Henoch Schonlein purpura in childhood: Leptin levels in Henoch-Schonlein purpura.
The elevated markers of hypercoagulability in children with Henoch-Schonleinpurpura. Henoch-Schönlein Purpura in adults: J Am Soc Nephrol. Familial cases of Berger's disease and anaphylactoid purpura. Anti-alpha-galactosyl antibodies and immune complexes in children with Henoch-Schonlein purpura or IgA nephropathy.
The Glomerular Disease Collaborative Network. Am J Kidney Dis. Henoch-Schönlein purpura nephritis and IgA nephropathy: Zhonghua Er Ke Za Zhi. Is there a crossroad between infections, genetics, and Henoch-Schönlein purpura?. Helicobacter pylori infection and dermatologic diseases.
Adult onset Schonlein-Henoch purpura associated with Helicobacter pylori infection, Komplex Thrombophlebitis. Henoch-Schönlein purpura associated with Helicobacter pylori infection in Komplex Thrombophlebitis child. Is Helicobacter pylori infection associated with Henoch-Schonlein purpura in Chinese children? Severe henoch-schonlein purpura induced by cytarabine. Incidence of Henoch-Schonlein purpura, Kawasaki disease, and rare vasculitides in children of different ethnic origins.
Primary vasculitis in a Norwegian community hospital: Epidemiology of renal disease in children in the region of Southern Croatia: A year review of regional renal biopsy databases. Fifteen-year experience of children with Henoch-Schonlein purpura in southern Taiwan, J Microbiol Immunol Infect.
Acute hemorrhagic edema of childhood. Komplex Thrombophlebitis Schonlein Purpura in children: Acute hemorrhagic edema of infancy: Age of onset as a risk factor of renal involvement in Henoch-Schönlein purpura.
J Med Assoc Thai. Henoch-Schonlein purpura in Chinese children and adults. Asian Pac J Allergy Immunol. Henoch-Schonlein purpura in children from western Turkey: Familial cases of Komplex Thrombophlebitis purpura in Taiwanese Aborigines, Komplex Thrombophlebitis. Relapses in patients with Henoch-Schonlein purpura: Analysis of patients from Komplex Thrombophlebitis single center. Risk of long term renal impairment and duration of follow up recommended for Henoch-Schonlein purpura with normal or minimal urinary findings: Diagnosis and management of Henoch-Schönlein purpura, Komplex Thrombophlebitis.
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